1-(tert-Butoxycarbonyl)-1H-indole-5-carboxylic acid

1-(tert-Butoxycarbonyl)-1H-indole-5-carboxylic acid - Names and Identifiers

Name	1H-Indole-1,5-dicarboxylic acid, 1-(1,1-dimethylethyl) ester
Synonyms	1-(tert-Butoxycarbonyl)-1H-indole-5-carboxylic acid 1-[(2-methylpropan-2-yl)oxycarbonyl]indole-5-carboxylic acid 1H-Indole-1,5-dicarboxylic acid, 1-(1,1-diMethylethyl) ester 1H-Indole-1,5-dicarboxylic acid, 1-(1,1-dimethylethyl) ester
CAS	188751-54-4

1-(tert-Butoxycarbonyl)-1H-indole-5-carboxylic acid - Physico-chemical Properties

Molecular Formula	C14H15NO4
Molar Mass	261.27
Storage Condition	2-8°C

1-(tert-Butoxycarbonyl)-1H-indole-5-carboxylic acid - Introduction

1H-Indole-1,5-dicarboxylic acid, 1-(1,1-dimethylethyl) ester is an acetyl-protected indole compound. The following is an introduction to its nature, use, preparation and safety information:

Nature:
1H-Indole-1,5-dicarboxylic acid, 1-(1,1-dimethylethyl) ester is a white or almost white crystal, which is insoluble in water at normal temperature and soluble in some organic solvents such as ether and dichloromethane. It is a stable compound that does not decompose or change under most common experimental conditions.

Use:
1H-Indole-1,5-dicarboxylic acid, 1-(1,1-dimethylethyl) ester is an important intermediate commonly used in organic synthesis. It can be used to synthesize various compounds containing indole structure, such as drugs, pesticides and dyes. It can also be used in synthetic chemistry to introduce the indole skeleton for the reaction of building complex organic molecules.

Method:
1H-Indole-1,5-dicarboxylic acid, 1-(1,1-dimethylethyl) ester is usually prepared by reacting indole with N-tert-butoxy carbene (N-Boc) acetylacetonate. A base catalyst is used during the reaction, and a suitable temperature and reaction time are maintained. After completion of the reaction, purification by crystallization or column chromatography is usually required.

Safety Information:
1H-Indole-1,5-dicarboxylic acid, 1-(1,1-dimethylethyl) ester is generally relatively safe under normal conditions of use. However, any chemical substance should be handled with caution and follow laboratory safety procedures. It may be irritating to the eyes, skin and respiratory tract, so contact with eyes and skin should be avoided and good ventilation should be maintained during operation. During use and storage, appropriate personal protective measures should be taken, such as wearing gloves, goggles and protective masks. If accidental exposure or discomfort occurs, seek medical attention immediately.

Last Update：2024-04-09 20:49:11